Pdf norfloxacin salts with benzenedicarboxylic acids. The crystallization of norfloxacin, an antibacterial fluoroquinolone compound, with different benzenedicarboxylic acids yields five novel pharmaceutical salts via molecular recognition. Show this safety data sheet to the doctor in attendance. The ldso of oral norfloxacin in rats and mice was greater than 4,000 mgkg.
Norfloxacin is used to treat certain bacterial infections in many different parts of the body. Norfloxacin is active mainly against gramnegative and grampositive pathogens. Norfloxacin belongs to the class of medicines known as quinolone antibiotics. Lists used were valid at the time of sds preparation.
Norfloxacin noroxin is an antibiotic prescribed to treat a variety of infections such as utis, gonorrhea, e. This medication belongs to a class of drugs known as quinolone antibiotics. Sigmaaldrich offers a number of norfloxacin products. Noroxin may be used for the treatment of urinary tract infections in patients with renal insufficiency. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Saar biotech norfloxacin plus metronidazole suspension. Factory low price norfloxacin cas 70458967 with high quality in usp standard. Norfloxacin may mask or delay the symptoms of syphilis. The following are mean concentrations of norfloxacin in various fluids and tissues measured 1 to 4 hours postdose after two 400mg doses. Norfloxacin is a synthetic, broadspectrum fluoroquinolone with antibacterial activity.
Norfloxacin cas number 70458967 systematic iupac name 1ethyl6fluoro4oxo7piperazin1yl1hquinoline3carboxylic acid identifiers atc code j01ma06 s01ax12 pubchem 4539 drugbank aprd00469 chemical data formula c16h18fn3o3 mol. Noroxin norfloxacin, msd is a synthetic antibacterial agent for oral administration. This study reports the efficiency of gammaray irradiation to degrade quinolone antibiotic, norfloxacin, in aqueous solution. Norfloxacin is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections and also used to treats gonorrhea.
Degradation of quinolone antibiotic, norfloxacin, in. At this dosage, the urinary concentration exceeds the mics for most urinary pathogens susceptible to. Download msdsmaterial safety data sheet of enrofloxacin. Buy norfloxacind5 cas 1015856571, a labeled antibacterial agent, from santa cruz biotechnology.
Cinzole, taj products manufacturing, pharmaceutical. It has a wide spectrum of activity and is rapidly bactericidal at low concentration. Buy norfloxacin cas 70458967, a fluorinated quinolone antibacterial agent, from santa cruz. Subjects and methods this was a randomised, doublemasked. Page 3 of 5 7 handling and storage precautions for safe handling. Norfloxacin c16h18fn3o3 cid 4539 structure, chemical names, physical and. It is freely soluble in glacial acetic acid, and very slightly soluble in ethanol, methanol and water noroxin is available in 400mg tablets.
Other companies are charging thousands of dollars to set up accounts and. Characterization and solubility study of norfloxacinpolyethylene glycol, polyvinylpyrrolidone and carbopol 974p solid dispersions. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. It is used to treat urinary tract infections, gynecological infections, inflammation of the prostate gland, gonorrhea and bladder infection. Niacinamide safety data sheet according to the federal final rule of hazard communication revised on 2012 hazcom 2012 jubilant life sciences limited page 3 of 7 collect recoverable product into labeled containers for recycling, recovery or disposal. Moxifloxacin has been linked to mild alt elevations during therapy and to rare instances of idiosyncratic acute liver injury with symptoms and jaundice. Identification of the substancemixture and of the companyundertaking product name. Norfloxacin cas 70458967 scbt santa cruz biotechnology. Eye drops were approved for use in children older than one year of age. View indentification, hazards, safety information, toxicity, regulations.
Norfloxacin hydrochloride is a broadspectrum antibiotic that is active against both grampositive and gramnegative bacteria, which functions by inhibiting dna gyrase. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Complicated urinary tract infections restricted use. We use cookies to ensure that we give you the best experience of our website. Corrado ml, struble we, peter c, hoagland v, sabbaj j. Norfloxacin is mainly used for the treatment of urinary tract infections which have high incidence during pregnancy especially in the first trimester. Norfloxacin concentrates in the renal tubules and bladder and is bactericidal against a wide range of aerobic grampositive and gramnegative organisms. The results of de60 and t 50% are presented in table 2. Norfloxacin nicotinate is a fluoroquinolone antibacterial agent that is a norfloxacin derivative with. Norfloxacin belongs to a group of antibiotics called fluoroquinolones, which work by killing the bacteria that cause the infections.
Norfloxacin, sold under the brand name noroxin among others, is an antibiotic that belongs to the class of fluoroquinolone antibiotics. Manufacturers norfloxacin is a prescription medication used to treat certain bacterial infections including urinary tract and prostate infections. The formation of solid dispersion with 25% of pvp, hpcl or carbopol, increased de60. In patients with a creatinine clearance rate of 30 mlmin1.
We ask that users who download significant portions of the database cite the. The dose constant was found to be dependent on the initial. The tolerability profile of norfloxacin, the first of a new generation of fluoroquinolone carboxylic acid antibacterials, has been defined in numerous laboratory animal and human trials. Norfloxacin inhibits activity of dna gyrase, thereby blocking bacterial dna replication. However, this medicine will not work for colds, flu, or other.
Certificate of analysis coa specification sheet pdf similar products. Adhere to everchanging regulations with our norfloxacin reference standards for environmental testing, cas number. Very bad and sometimes deadly liver problems have happened with norfloxacin. Norfloxacin is an antibiotic in a group of drugs called fluoroquinolones florokwinolones. Moxifloxacin is a fourth generation fluoroquinolone with expanded activity against grampositive bacteria as well as atypical pathogens. Sds are documents that provide critical information about hazardous chemicals. Uncomplicated urethral and cervical gonorrhea however this indication is no longer considered to be effective by some experts due to bacterial resistance.
There was a significant difference in de60 as well as t 50% values between norfloxacin and its solid dispersions. Laboratory batch experiments were conducted to determine the pseudofirst order degradation kinetics of norfloxacin in the concentration ranges of 3. Sds of norfloxacin, safety data sheets, cas 70458967. Norfloxacin is used to treat a variety of bacterial infections.
Its empirical formula is c16 h18 fn3 o3 and the structural. It is freely soluble in glacial acetic acid and very slightly soluble in ethanol, methanol and water chibroxin norfloxacin ophthalmic solution 0. Norfloxacin nicotinate cas 118803819 scbt santa cruz. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, lightcolored stools, throwing up, or yellow skin or eyes. Norfloxacin exhibited the lowest de60 but highest t 50%. Norfloxacin is a white to pale yellow crystalline powder with a molecular weight of 319. It works by killing bacteria or preventing their growth. Whether administered for moderate or protracted periods. Extreme high moderate low section 1 chemical product and company identification product name norfloxacin statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Material safety data sheet norfloxacin sc215586 hazard alert code key. The serum protein binding of norfloxacin is between 10 and 15%. The information contained in this data sheet represents the best information currently available to us. Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Norfloxacin manufacturers, india, exporter, cas no.
1180 1264 794 1255 1214 193 196 598 140 592 1448 441 1299 464 787 1541 655 1084 963 1167 314 665 1026 959 333 831 1593 822 1550 1188 1419 1101 627 1243 1229 1560 1219 1475 130 306 525 666 775 1040 1434 9 33 329 648 3